Preparation and Determination of the Characteristics of Hydrogel Membrane of Poly-Vinyl Alchol, Starch and Chitosan

Document Type : Research Paper

Authors

1 Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran

2 Biomaterial Department of Iran Polymer and Petrochemical Institute, Tehran, Iran

3 Faculty of Advanced Sciences and Technologies, Department of Biotechnology, University of Isfahan, Iran

4 Department of Biology, University of Isfahan, Isfahan, Iran

Abstract

In this study, a new kind of crosslinking film of polyvinyl alcohol, starch, and chitosan was obtained by alternating freeze-thaw cycles, and its various properties such as swelling rate, water vapor transmission rate, mechanical properties, and morphology were checked using electron microscopy. The results of this study showed that the hydrogel, made by providing a damp environment and the ability to pass water vapor in the range 720-1680 g/m2, has acceptable mechanical properties so that the fracture stress in polyvinyl alcohol was equal to 0.642 kgf/ mm2, which reached 0.372 kgf/ mm2 with the introduction of starch and 0.2475 kgf/ mm2 with the addition of chitosan. When we add starch and chitosan to polyvinyl alcohol at the same time, the fracture stress reaches 0.261 kgf/ mm2. In the sample containing pure polyvinyl alcohol, the elastic strain is equal to 6.157 and with the addition of starch, this value reaches 4.625 and with the addition of chitosan, this value reaches 5.70. Adding starch and chitosan to polyvinyl alcohol increases the modulus and toughness and decreases the flexibility of the polyvinyl alcohol hydrogel membrane. Images of SEM from a cross-section of hydrogel membrane fracture show that hydrogel membranes containing polyvinyl alcohol are very smooth and monotonous; however, when starch and chitosan are added to polyvinyl alcohol, the porosity will increase.

Keywords

Main Subjects


[1] Y. XiongX. Zhang,   X. Ma,   W. Wang,   F. Yan, X. Zhao,   X. ChuW. Xu  and  Ch. Sun, " A review of the properties and applications of bioadhesive hydrogels  ", Polymer Chemistry, Issue 26, 2021, pp. 3721-3739.
[2] I. A. KhalilB. SalehD. M. IbrahimC. Jumelle,f   A. YungR. Dana and  N. Annabi , " Ciprofloxacin-loaded bioadhesive hydrogels for ocular applications ", Biomater. Sci., 2020, 8, 5196-5209.
[3] M.F. Akhtar, M. Hanif, N.M. Ranjha, "Methods of Synthesis of Hydrogels: A Review", Saudi Pharm. J., Vol. 24, 2016, pp.554-559.
[4] R. R-Rodríguez, H. E-Andrews, C. V-Martínez and Z. Y. G-Carvajal "Composite hydrogels based on gelatin, chitosan and polyvinyl alcohol to biomedical pplications: a review", International Journal of Polymeric Materials and Polymeric Biomaterials Volume 69, 2020 - Issue 1
[5] B. E. Karaogul, E. Altuntas, T. Salan and M. H. Alma " The Effects of Novel Additives Used in PVA/Starch Biohybrid Films", Submitted: July 2nd 2018Reviewed: September 28th 2018Published: December 19th 2018 DOI: 10.5772/intechopen.81727.
[6] A. Jayakumar 1H. K V 1S.T S 1M. Joseph 1Sh. Mathew 1P. G 2I. C Nair 3R. E K 4" Starch-PVA composite films with zinc-oxide nanoparticles and phytochemicals as intelligent pH sensing wraps for food packaging application ". Int J Biol Macromol. 2019 Sep 1;136:395-403. doi: 10.1016/j.ijbiomac.2019.06.018. Epub 2019 Jun 4.
 [7] Y. Fan, F. Picchioni, " Modification of starch: A review on the application of “green” solvents and controlled functionalization  ", Carbohydrate Polymers Volume 241, 1 August 2020, 116350.
[8] K. Bashir and M. Aggarwal, Physicochemical, structural and functional properties of native and irradiated starch: a review , J Food Sci Technol. 2019 Feb; 56(2): 513–523. Published online 2019 Jan 1. doi: 10.1007/s13197-018-3530-2. PMCID: PMC6400748
[9] Z.H. Xiong, P. Fei, "Physical and chemical modification of starches: A review", Vol. 13, 57(12), 2017, pp.2691-2705.
[10] U. Shah, A. Gani, B. Ahmad Ashwar, A. Shah, M. Ahmad, A. Gani, A. Idrees, F.A. Wani Masoodi, "A review of the recent advances in starch as active and nanocomposite packaging film", Vol. 1, 2015, pp.1115640-1115649.
[11] Ch. Sh.Karua, A.Sahoo, "Synthesis and characterization of starch/chitosan composites ", Materials Today, Volume 33, Part 8, 2020, Pages 5179-5183
[12] Gh.Sargazi, D.Afzali, A.Mostafavi, A.Shadman, B.Rezaee, P.Zarrintaj, M.Saeb, S.Ramakrishna, M.Mozafari, Chitosan/polyvinyl alcohol nanofibrous membranes: towards green super-adsorbents for toxic gases , Materials Science , Volume 5, Issue 4, April 2019, e01527.
[13] H M Manal, Different fabrication methods of tissue engineering, An International Journal of Medicine, Volume 111, Issue suppl_1, December 2018, hcy200.224.
[14] J. D. Carrera, D. A. V. Narváez, M. Leon, J. F. Alvarez, " Effect of Starch Oxidation Degree on the  Properties of Hydrogels from Dialdehyde Starch and Polyvinyl Alcohol  ", Journal A Bimonthly Peer-Review Journal (ISSN: 2415-6698).
[15] N. MallickD. Pal, and A. B. Soni, "Corn-starch/polyvinyl alcohol bio-composite film for food packaging application", AIP Conference Proceedings 2201, 020005  (2019); https://doi.org/ 10.1063/ 1.5141429.
 [16] Y. YingY. WuJ. Huang , Preparation and characterization of chitosan/poly(vinyl alcohol)/graphene oxide films and studies on their antibiofilm formation activity . J Biomed Mater Res A. 2020 Oct;108(10):2015-2022. doi: 10.1002/ jbm.a.36961. Epub 2020 May 4.
[17] I. P. MerluscaD. S. MatiutG. LisaM. SilionL. GradinaruS. Oprea & I. M. Popa , "Preparation and characterization of chitosan–poly(vinyl alcohol)–neomycin sulfate films ", Polymer Bulletin vol. 75, pages3971–3986 (2018).
[18] Gh.D.Afzali, A.Mostafavi, A.Shadman, B. Rezaee, P.Zarrintaj, M.Saeb, S.Ramakrishna M.Mozafari "Chitosan/polyvinyl alcohol nanofibrous membranes: towards green super-adsorbents for toxic gases",Volume 5, Issue 4, April 2019, e01527.
[19] S. Nikzad,B.  Hashemi, Z.M. Hassan, H. Mozdarani, "The cell survival of F10B16 melanoma and 4T1 breast adenocarcinoma irradiated to gamma radiation using the MTT assay based on two different calculation methods", Journal of Biomedical Physics & Engineering, Vol. 3(2), 2013, pp.29-36.